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Rho Kinase-Dependent Activation of SOX9 in Chondrocytes.

Authors :
Haudenschild, Dominik R.
Jianfen Chen
Pang, Nina
Lotz, Martin K.
D'Lima, Darryl D.
Source :
Arthritis & Rheumatism. Jan2010, Vol. 62 Issue 1, p191-200. 10p. 2 Diagrams, 4 Graphs.
Publication Year :
2010

Abstract

The article discusses a study which investigated the interaction between Rho kinase (ROCK) and transcription factor SOX9. Study authors transfected human SWI353 chondrosarcoma cells with constructs coding for RhoA, ROCK, Lira kinase and SOX9. They examined the interaction between ROCK and SOX9 on purified proteins. They found that SOX9 contains a consensus phosphorylation site for ROCK, and that ROCK directly phosphorylated SOX9.

Subjects

Subjects :
*TRANSCRIPTION factors
*CYTOLOGICAL research
*PROTEIN research
*PHOSPHORYLATION
*PROTEIN kinases

Details

Language :
English
ISSN :
00043591
Volume :
62
Issue :
1
Database :
Academic Search Index
Journal :
Arthritis & Rheumatism
Publication Type :
Academic Journal
Accession number :
52043712
Full Text :
https://doi.org/10.1002/art.25051
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