Back to Search
Start Over
First-line therapy for ovarian cancer with carboplatin followed by paclitaxel–gemcitabine (SCOTROC5): A feasibility study and comparative analysis of the SCOTROC series
- Source :
-
European Journal of Cancer . Jul2010, Vol. 46 Issue 11, p2020-2026. 7p. - Publication Year :
- 2010
-
Abstract
- Background: We have conducted a series of four feasibility studies in stage Ic–IV ovarian cancer exploring six sequential first-line schedules with the same entry criteria in a total of 339 patients. Here we present the results of the sixth study, and an analysis of the overall series. Methods: In this trial patients received 4 cycles of carboplatin AUC 7 every 3 weeks, followed by 4 cycles of concurrent paclitaxel 175mg/m2 (day 1) and gemcitabine 1000mg/m2 (days 1 and 8) every 3 weeks. The primary end-point of the trial was feasibility of administering all cycles of planned chemotherapy to >60% of patients. Results: Fifty-four patients were recruited to the trial between June 05 and June 06. A total of 40 (74.1%) patients received all 8 cycles of treatment. Reasons for early discontinuation included toxicity (n =8) and disease progression (n =4). The overall response rate was 73.7%, and the median progression free survival (PFS) was 14.2 months with a median follow-up of 24 months. A comparative analysis of all six regimens from the SCOTROC series suggests that the sequential schedule in which paclitaxel was given weekly (median PFS 19.5m) is most effective. Conclusion: The sequential schedule explored in this trial is feasible, but comparative efficacy analysis suggests that trials involving weekly paclitaxel should be prioritised for further study. [Copyright &y& Elsevier]
- Subjects :
- *OVARIAN cancer
*CANCER treatment
*PACLITAXEL
*DRUG therapy
*DRUG administration
Subjects
Details
- Language :
- English
- ISSN :
- 09598049
- Volume :
- 46
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- European Journal of Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 51990465
- Full Text :
- https://doi.org/10.1016/j.ejca.2010.03.006