Gene Knockdown of the N-Methyl-D-Aspartate Receptor NR1 Subunit with Subcutaneous Small Interfering RNA Reduces Inflammation-induced Nociception in Rats.

The article focuses on a study which investigated the impact of subcutaneous injection of small interfering RNA (siRNA) targeting the NR1 subunit of the N-methyl-D-aspartate receptor on NR1 gene expression silencing and reducing inflammatory nociception in rats. Male Sprague-Dawley rats were employed in the experiment which received intradermal injection of NR1 siRNA while also undergoing injection of formalin. Results showed that NR1 siRNA injection resulted to the elimination of the nociception induced by formalin and complete Freund's adjuvant stimuli. It concluded that NR1 siRNA can be used in the treatment of inflammatory pain induced or maintained by peripheral nociceptor activity.