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Dysfunctional B-cell responses during HIV-1 infection: implication for influenza vaccination and highly active antiretroviral therapy
- Source :
-
Lancet Infectious Diseases . Jul2010, Vol. 10 Issue 7, p499-503. 5p. - Publication Year :
- 2010
-
Abstract
- Summary: Although HIV-1 infection does not directly target B cells, B-cell numbers are reduced and their function is impaired during HIV infection. Antibody titres against antigens previously encountered through vaccination or natural infection are low in patients with HIV. Intrinsic B-cell defects might be involved in the impairment of humoral immunity during early HIV infection. Abnormal T-cell activation and the altered expression of molecules involved in the B-cell homing process cause dysfunctional interaction between T and B cells in the germinal centres of lymphoid tissues, which might impair B-cell responses during HIV infection. Class-switch recombination is also impaired in individuals with HIV. Protective immune responses against T-cell-dependent antigens, including influenza antigens, rely on the production of neutralising antibodies. Impaired B-cell responses during HIV infection could therefore hamper the effectiveness of vaccinations against seasonal influenza or the new pandemic influenza A H1N1 vaccines in individuals with HIV. By maintaining B-cell responses, highly active antiretroviral therapy might improve the efficacy of influenza vaccines in individuals with HIV. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 14733099
- Volume :
- 10
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Lancet Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 51845642
- Full Text :
- https://doi.org/10.1016/S1473-3099(10)70117-1