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Effect of treating co-infections on HIV-1 viral load: a systematic review
- Source :
-
Lancet Infectious Diseases . Jul2010, Vol. 10 Issue 7, p455-463. 9p. - Publication Year :
- 2010
-
Abstract
- Summary: Co-infections contribute to HIV-related pathogenesis and often increase viral load in HIV-infected people. We did a systematic review to assess the effect of treating key co-infections on plasma HIV-1-RNA concentrations in low-income countries. We identified 18 eligible studies for review: two on tuberculosis, two on malaria, six on helminths, and eight on sexually transmitted infections, excluding untreatable or non-pathogenic infections. Standardised mean plasma viral load decreased after the treatment of co-infecting pathogens in all 18 studies. The standardised mean HIV viral-load difference ranged from −0·04 log10 copies per mL (95% CI −0·24 to 0·16) after syphilis treatment to −3·47 log10 copies per mL (95% CI −3·78 to −3·16) after tuberculosis treatment. Of 14 studies with variance data available, 12 reported significant HIV viral-load differences before and after treatment. Although many of the viral-load reductions were 1·0 log10 copies per mL or less, even small changes in plasma HIV-RNA concentrations have been shown to slow HIV progression and could translate into population-level benefits in lowering HIV transmission risk. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 14733099
- Volume :
- 10
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Lancet Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 51845637
- Full Text :
- https://doi.org/10.1016/S1473-3099(10)70093-1