Nematode parasite genes: what's in a name?

The central theme of Shakespeare''s Romeo and Juliet is that names are meaningless, artificial constructs, detached from any underlying reality. By contrast, we argue that a well chosen gene name can concisely convey a wealth of relevant biological information. A consistent nomenclature adds transparency that can have a real impact on our understanding of gene function. Currently, genes in parasitic nematodes are often named ad hoc, leading to confusion that can be resolved by adherence to a nomenclature standard adapted from Caenorhabditis elegans. We demonstrate this with ligand-gated ion-channels and propose that the flood of genome data and differences between parasites and the free living C. elegans will require modification of the standard. [Copyright &y& Elsevier]