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Meta-analysis of BDNF Val66Met polymorphism association with treatment response in patients with major depressive disorder
- Source :
-
European Neuropsychopharmacology . Aug2010, Vol. 20 Issue 8, p535-544. 10p. - Publication Year :
- 2010
-
Abstract
- Abstract: The aim of our meta-analysis was to assess the association between BDNF Val66Met polymorphism and treatment response in patients with MDD. 8 studies that included data from 1115 subjects were identified. We tested two phenotypes: response rate and remission rate. OR was used as a measure of the effect of the association in a fixed/random effect model. Meta-analysis was performed for genotypes Met/Met versus Val/Val, Val/Met versus Val/Val, Met/Met versus Val/Met, Val/Met+Met/Met versus Val/Val, Met/Met versus Val/Val+Val/Met, and Met allele versus Val allele. When all groups were pooled, a significant association of Val/Met genotype and increased response rate was found in comparison to Val/Val in overall population (OR=1.66, 95%CI=1.07–2.57, P =0.02). In the subgroup analysis, similar result was shown in Asian population (OR=1.83, 95%CI=1.03–3.26, P =0.04), but not in Caucasian population. We didn''t observe a significant association of BDNF Val66Met polymorphism with remission rate. This meta-analysis demonstrates the association between BDNF Val66Met polymorphism and treatment response in patients with MDD, and Val66Met heterozygous patients have a better response rate in comparison to Val/Val homozygote patients, especially in Asian population. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0924977X
- Volume :
- 20
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- European Neuropsychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 51844494
- Full Text :
- https://doi.org/10.1016/j.euroneuro.2009.12.005