Large Relaxivity Enhancement of Paramagnetic Lipid Nanoparticles by Restricting the Local Motions of the GdIII Chelates.

The article presents a study that examines the use of DOTA-like GdIII chelates in the high relaxivity enhancement of micelles and liposomes. It states that four complexes were synthesized and alkylated through alkyl bromide. It mentions that amphiphilic complexes such as GdDOTAGAC12 and GdDOTA(GAC12)2 were yielded. It reveals that the GdDOTA derivative enables to incorporate micelles into liposomes which reflects unprecedented relaxivity enhancement.