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Serum amino-terminal pro-brain natriuretic peptide in hematological patients with neutropenic fever: a prospective comparison with C-reactive protein.
- Source :
-
Leukemia & Lymphoma . Jun2010, Vol. 51 Issue 6, p1040-1046. 7p. 3 Charts, 3 Graphs. - Publication Year :
- 2010
-
Abstract
- Serum amino-terminal pro-brain natriuretic peptide (NT-proBNP) is considered as a prognostic marker in patients with severe sepsis or septic shock, but no data are available on NT-proBNP kinetics in hematological patients with neutropenic fever. Altogether 70 hematological patients with neutropenic fever were included in this prospective study. NT-proBNP and C-reactive protein (CRP) were determined at the beginning of the neutropenic fever (d0) and then daily up to 3–4 days. The median NT-proBNP (interquartile range) increased from 127 (57–393) ng/L on d0 to 542 (194–1385) ng/L on d4. The increment of CRP was from 35 (17–61) mg/L on d0 to 109 (56–109) mg/L on d2. Neither serial NT-proBNP nor CRP predicted development of severe sepsis, but NT-proBNP was significantly higher in patients with previous cardiovascular disease than in those without. NT-proBNP seemed to reflect cardiac distress, but it did not help to predict the development of severe sepsis in this patient group. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SERUM
*C-reactive protein
*SEPSIS
*CARDIOVASCULAR diseases
*BLOOD plasma
Subjects
Details
- Language :
- English
- ISSN :
- 10428194
- Volume :
- 51
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Leukemia & Lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 51317678
- Full Text :
- https://doi.org/10.3109/10428191003743478