Back to Search
Start Over
Role of PD-1 in regulating acute infections
- Source :
-
Current Opinion in Immunology . Jun2010, Vol. 22 Issue 3, p397-401. 5p. - Publication Year :
- 2010
-
Abstract
- While the role of PD-1 in inhibiting immunity during chronic infections is well established, its functions during acute infections are much less clear. The PD-1 pathway can dampen CD8 T cell responses during some acute infections and restrain responses by ‘helpless’ CD8 memory T cells. An emerging role for PD-1 in innate immunity has been revealed by recent studies showing that PD-1 can limit function of DC and macrophages as well as T cell independent B cell responses. Thus, PD-1 can influence adaptive immune responses during acute infections, though precisely how this regulation occurs is only just beginning to be appreciated. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 09527915
- Volume :
- 22
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Current Opinion in Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 51293084
- Full Text :
- https://doi.org/10.1016/j.coi.2010.03.007