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Polycomb group protein-mediated repression of transcription
- Source :
-
Trends in Biochemical Sciences . Jun2010, Vol. 35 Issue 6, p323-332. 10p. - Publication Year :
- 2010
-
Abstract
- The polycomb group (PcG) proteins are essential for the normal development of multicellular organisms. They form multi-protein complexes that work as transcriptional repressors of several thousand genes controlling differentiation pathways during development. How the PcG proteins work as transcriptional repressors is incompletely understood, but involves post-translational modifications of histones by two major PcG protein complexes: polycomb repressive complex 1 and polycomb repressive complex 2. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 09680004
- Volume :
- 35
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Trends in Biochemical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 51292816
- Full Text :
- https://doi.org/10.1016/j.tibs.2010.02.009