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Genetic association between TNF-α -308 G>A polymorphism and longitudinal weight change during clozapine treatment.
- Source :
-
Human Psychopharmacology: Clinical & Experimental . Jun2010, Vol. 25 Issue 4, p303-309. 7p. 2 Charts, 1 Graph. - Publication Year :
- 2010
-
Abstract
- Objective The aim of the study was to investigate the association between genetic variation in the tumor necrosis factor-alpha (TNF-α) gene and longitudinal weight change during long-term clozapine treatment. Methods Fifty-five patients with refractory schizophrenia treated with clozapine for 8 years were recruited. Gender, age, treatment response to clozapine in the first 14 months, baseline BMI, clozapine dose, concomitant use of mood stabilizers and other antipsychotics, and -308 G > A polymorphism in the human TNF-α gene were analyzed using generalized estimating equations. Results In addition to having a lower baseline BMI (p = 0.0013) and a longer treatment time (p = 0.050), the -308 GG carriers gained significantly more weight than the -308 A allele carriers (p = 0.0084) during 8 years of clozapine treatment, after controlling for other non-genetic factors. Conclusions The -308 G > A genetic variant of the TNF-α gene is associated with longitudinal weight change during clozapine treatment. Follow-up duration is an important factor to consider when performing pharmacogenetic study of clozapine-induced weight gain. Copyright © 2010 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TUMOR necrosis factors
*CLOZAPINE
*BODY weight
*WEIGHT gain
*BODY mass index
Subjects
Details
- Language :
- English
- ISSN :
- 08856222
- Volume :
- 25
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Human Psychopharmacology: Clinical & Experimental
- Publication Type :
- Academic Journal
- Accession number :
- 51176108
- Full Text :
- https://doi.org/10.1002/hup.1122