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Is a Single Focus of Low-Grade Prostate Cancer Diagnosed on Saturation Biopsy Predictive of Clinically Insignificant Cancer?
- Source :
-
Urologia Internationalis . May2010, Vol. 84 Issue 4, p440-444. 5p. 2 Charts. - Publication Year :
- 2010
-
Abstract
- Objectives: To evaluate the incidence of indolent prostate cancer (PCa; <0.5 ml cancer and Gleason score, GS, ≤6) in men with microfocal PCa diagnosed on saturation biopsy (SPBx) submitted to radical retropubic prostatectomy. Methods: From January 2005 to December 2008, 413 patients (median age 61.5 years) underwent SPBx (median 30 cores). A single neoplastic microfocus (5% or less of cancer in a single core) was found in 55 men and all patients underwent retropubic prostatectomy. Median PSA was equal to 8.2 ng/ml, digital rectal examination was negative and GS was 6 in 40 cases and not evaluable in 15 cases. Results: Prostatectomy specimens showed a significant cancer in 48/55 (87.3%) patients with a median GS of 6.2 (range 5–8), presence of extraprostatic extension and positive surgical margins in 15 (27.3%) and 8 (14.5%) cases, respectively. Six patients had an indolent PCa, and in 1 case no tumor was found. Conclusions: Patients with a single microfocal PCa diagnosed on SPBx corresponded to an insignificant cancer in surgical specimens only in 12.7% of cases, but they should be informed that they may harbor more aggressive disease with a risk of non-organ-confined cancer that in our series was 27.3%. Copyright © 2010 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00421138
- Volume :
- 84
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Urologia Internationalis
- Publication Type :
- Academic Journal
- Accession number :
- 51134108
- Full Text :
- https://doi.org/10.1159/000296293