Diels--Alder Bioconjugation of Diene-Modified Oligonucleotides.

Authors :: Hill, Kenneth W.
Taunton-Rigby, Jon
Carter, Jeffrey D.
Kropp, Eric
Vagle, Kurt
Pieken, Wolfgang
McGee, Danny P.C.
Husar, Gregory M.
Leuck, Michael
Anziano, Dominic J.
Sebesta, David P.
Source :: Journal of Organic Chemistry. 8/10/2001, Vol. 66 Issue 16, p5352. 7p. 8 Diagrams.
Publication Year :: 2001
Abstract: Evaluates the acceleration of Diels-Alder reactions for the bioconjugation of diene-modified oligonucleotides. Synthesis of diene phosphoramidite reagents; Modification of synthetic oligonucleotides; Use of phosphoramidite method for the modification.