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The case of a 48 year-old woman with bizarre and complex delusions.
- Source :
-
Nature Reviews Neurology . Mar2010, Vol. 6 Issue 3, p175-180. 6p. 2 Diagrams, 1 Chart. - Publication Year :
- 2010
-
Abstract
- <bold>Background: </bold>A 48 year-old woman presented with an 18 month history of bizarre and complex delusions on a background of social, behavioral and cognitive decline over several years. Her psychosis progressed despite receiving high doses of antipsychotics. The patient's father also had a psychotic episode in his 40s. He subsequently developed motor neuron disease, which caused his death at 68 years of age.<bold>Investigations: </bold>Physical examination, neuropsychological testing, nerve conduction studies, brain MRI and transcranial magnetic stimulation.<bold>Diagnosis: </bold>On the basis of the patient's age at onset of the delusions, imaging findings and family history, a diagnosis of frontotemporal dementia (FTD) was favored over a primary psychotic disorder. The ubiquitin-positive and TAR DNA binding protein 43-positive inclusions that were found at autopsy confirmed the diagnosis of FTD.<bold>Management: </bold>The patient was treated with various antipsychotics at high doses; however, her delusions continued to progress. No disease-specific treatments for FTD currently exist. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DISEASES in women
*DELUSIONS
*COGNITION disorders
*PSYCHOSES
*ANTIPSYCHOTIC agents
*MOTOR neuron diseases
*BRAIN
*MAGNETIC resonance imaging
*NEUROPSYCHOLOGICAL tests
*NEURAL conduction
*PHYSICAL diagnosis
*RESEARCH funding
*DNA-binding proteins
*DISEASE complications
*FRONTOTEMPORAL dementia
*DIAGNOSIS
BRAIN metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 17594758
- Volume :
- 6
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Nature Reviews Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 50366290
- Full Text :
- https://doi.org/10.1038/nrneurol.2010.3