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IL-8 in Cerebrospinal Fluid from Children with Acute Encephalopathy is Higher than in that from Children with Febrile Seizure.
- Source :
-
Scandinavian Journal of Immunology . Jun2010, Vol. 71 Issue 6, p447-451. 5p. 1 Diagram, 2 Charts. - Publication Year :
- 2010
-
Abstract
- We identify possible differences in the cytokine/chemokine profiles in cerebrospinal fluid (CSF) from children with encephalopathy and febrile seizure. Interleukin (IL)-1β, 2, 4, 5, 6, 7, 8, 10, 12, 13, 17, interferon-γ, tumour necrosis factor-α, granulocyte colony-stimulating factor, granulocyte monocyte colony-stimulating factor, monocyte chemoattractant protein-1 and macrophage inflammatory protein-1β were measured simultaneously in CSF supernatants from children with encephalopathy ( n = 8), febrile seizure ( n = 16) and fever without neurological complications ( n = 8). IL-8 in CSF from children with encephalopathy was significantly elevated compared to that in CSF from children with febrile seizure and fever without neurological complications. IL-8 in CSF was also higher than serum IL-8, suggesting that increased IL-8 was generated from glia cells or astrocytes, not by leakage from serum. Increased IL-8 in CSF in encephalopathy may protect against severe brain damage. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HEPATIC encephalopathy
*CEREBROSPINAL fluid
*CHEMOKINES
*FEBRILE seizures
Subjects
Details
- Language :
- English
- ISSN :
- 03009475
- Volume :
- 71
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Scandinavian Journal of Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 50353149
- Full Text :
- https://doi.org/10.1111/j.1365-3083.2010.02391.x