Complications Related to Osteobiologics Use in Spine Surgery.

The article presents a study which identifies the complications in patients following the use of bone morphogenetic proteins (BMP) in spinal fusion surgery. The study conducted a systemic review of literatures published from 1990 to June 2009 in the Cochrane Collaboration Library, EMBASE and MEDLINE. Results show that multiple complications including resorption, subsidence and dysphagia are associated following the use of recombinant BMP-2 in lumbar and cervical spinal fusion surgery.