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Smoothened Mutants Reveal Redundant Roles for Shh and Ihh Signaling Including Regulation of L/R...

Authors :
Zhang, Xiaoyan M.
Ramalho-Santos, Miguel
McMahon, Andrew P.
Source :
Cell. 7/27/2001, Vol. 106 Issue 2, p781. 12p. 67 Color Photographs, 1 Diagram.
Publication Year :
2001

Abstract

Shows that smoothened (Smo) mutants acts epistatic to patched to mediate Sonic and Indian compound mutants in the early mouse embryo development. Genetic analysis of Smo function in mice; Role of hedgehog signaling in mouse left/right (L/R) axis development; Examination of pathways controlling left/right situs.

Subjects

Subjects :
*MICE
*MUTAGENESIS
*EMBRYOS

Details

Language :
English
ISSN :
00928674
Volume :
106
Issue :
2
Database :
Academic Search Index
Journal :
Cell
Publication Type :
Academic Journal
Accession number :
5018093