Preparation of Potent Cytotoxic Ribonucleases by Cationization: Enhanced Cellular Uptake and...

Authors :: Futami, Junichiro
Maeda, Takashi
Kitazoe, Midori
Nukui, Emiko
Tada, Hiroko
Seno, Masaharu
Kosaka, Megumi
Yamada, Hidenori
Source :: Biochemistry. 6/26/2001, Vol. 40 Issue 25, p7518. 7p. 4 Color Photographs, 2 Black and White Photographs, 1 Diagram, 1 Chart, 2 Graphs.
Publication Year :: 2001
Abstract: Examines the effects of the modification of the carboxyl groups with amines having a side chain moiety on the interaction of ribonuclease (RNase) with ribonuclease inhibitor. Ribonucleolytic activity; Enzymatic activity; Inactivation of native RNase; Cytotoxicity of the RNase derivatives; Adsorption of more cationic RNases; Efficiency of cellular uptake.

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