Dimetalation of Pyrazines. A One-Pot Synthesis of Multisubstituted Pyrazine C-Nucleosides.

Authors :: Liu, Weimin
Wise, Dean S.
Townsend, Leroy B.
Source :: Journal of Organic Chemistry. 7/13/2001, Vol. 66 Issue 14, p4783. 4p. 4 Diagrams, 1 Chart.
Publication Year :: 2001
Abstract: Studies the synthesis of pyrazine C-nucleosides using sequential dilithiation-addition method. Dilithiopyrazine and electrophile reaction; Aromatic peaks of the O-benzyl groups on the sugar moiety; Result of the nucleophilic substitution by phenylthiolithium; Ortho relationship between the methyl peaks.

Subjects :: *NUCLEOSIDES
*PYRIDAZINES
*ADDITION reactions
*NUCLEOPHILIC reactions
*BIOSYNTHESIS

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