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Identification of Specific Lipid-binding Sites in Integral Membrane Proteins.
- Source :
-
Journal of Biological Chemistry . 4/2/2010, Vol. 285 Issue 14, p10519-10526. 8p. 1 Diagram, 5 Charts, 1 Graph. - Publication Year :
- 2010
-
Abstract
- Protein-lipid interactions are increasingly recognized as central to the structure and function of membrane proteins. However, with the exception of simplified models, specific protein-lipid interactions are particularly difficult to highlight experimentally. Here, we used molecular dynamics simulations to identify a specific protein-lipid interaction in lactose permease, a prototypical model for transmembrane proteins. The interactions can be correlated with the functional dependence of the protein to specific lipid species. The technique is simple and widely applicable to other membrane proteins, and a variety of lipid matrices can be used. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MEMBRANE proteins
*PROTEINS
*LIPIDS
*BIOLOGICAL membranes
*MOLECULAR dynamics
Subjects
Details
- Language :
- English
- ISSN :
- 00219258
- Volume :
- 285
- Issue :
- 14
- Database :
- Academic Search Index
- Journal :
- Journal of Biological Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 49804093
- Full Text :
- https://doi.org/10.1074/jbc.M109.068890