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Delayed re-endothelialization with rapamycin-coated stents is rescued by the addition of a glycogen synthase kinase-3β inhibitor.
- Source :
-
Cardiovascular Research . May2010, Vol. 86 Issue 2, p338-345. 8p. 4 Graphs. - Publication Year :
- 2010
-
Abstract
- Aims: Drug-eluting stents (DESs) reduce neointima area and in-stent restenosis but delay re-endothelialization. Recently, we demonstrated that pharmacological expansion and functional enhancement of endothelial progenitor cells (EPCs) can be achieved by treatment with a glycogen synthase kinase-3β inhibitor (GSKi)—even for feeble cells derived from coronary artery disease patients. GSKi treatment enhanced EPC adhesion via up-regulated expression of the α-4 integrin, ameliorated re-endothelialization, and reduced neointima formation in denuded murine arteries. Hence, we hypothesized that GSKi-coated stents (GSs) will enhance EPC adhesion and attenuate delayed vascular healing associated with rapamycin, a key DES agent. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 00086363
- Volume :
- 86
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Cardiovascular Research
- Publication Type :
- Academic Journal
- Accession number :
- 49779071
- Full Text :
- https://doi.org/10.1093/cvr/cvq047