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Genome-wide association study of height and body mass index in Australian twin families.
- Source :
-
Twin Research & Human Genetics . Apr2010, Vol. 13 Issue 2, p179-193. 15p. 1 Diagram, 5 Charts, 4 Graphs. - Publication Year :
- 2010
-
Abstract
- Human height and body mass index are influenced by a large number of genes, each with small effects, along with environment. To identify common genetic variants associated with these traits, we performed genome-wide association studies in 11,536 individuals composed of Australian twins, family members, and unrelated individuals at approximately 550,000 genotyped SNPs. We identified a single genome-wide significant variant for height (P value=1.06x10(-9)) located in HHIP, a well-replicated height-associated gene. Suggestive levels of association were found for other known genes associated with height (P values<1x10(-6)): ADAMTSL3, EFEMP1, GPR126, and HMGA2; and BMI (P values<1x10(-4)): FTO and MC4R. Together, these variants explain less than 2% of total phenotypic variation for height and 0.5% for BMI. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 18324274
- Volume :
- 13
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Twin Research & Human Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 49194341
- Full Text :
- https://doi.org/10.1375/twin.13.2.179