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Sites of distant recurrence and clinical outcomes in patients with metastatic triple-negative breast cancer: high incidence of central nervous system metastases.
- Source :
-
Cancer (0008543X) . 11/15/2008, Vol. 113 Issue 10, p2638-2645. 8p. 3 Charts, 2 Graphs. - Publication Year :
- 2008
-
Abstract
- <bold>Background: </bold>The purpose of the current study was to characterize the outcomes of patients with metastatic triple-negative breast cancers, including the risk and clinical consequences of central nervous system (CNS) recurrence.<bold>Methods: </bold>Using pharmacy and pathology records, a study group of 116 patients who were treated for metastatic triple-negative breast cancer at Dana-Farber Cancer Institute between January 2000 and June 2006 was identified.<bold>Results: </bold>The median survival from time of metastatic diagnosis was 13.3 months. Sixteen patients (14%) were diagnosed with CNS involvement at the time of initial metastatic diagnosis; overall, 46% of patients were diagnosed with CNS metastases before death. The median survival after a diagnosis of CNS metastasis was 4.9 months. The age-adjusted and race-adjusted rate of death for patients whose first presentation included a CNS metastasis was 3.4 times (95% confidence interval, 1.9-6.1 times) that of patients without a CNS lesion at the time of first metastatic presentation. Of the 53 patients who developed brain metastases, only 3 patients were judged to have stable or responsive systemic disease in the face of progressive CNS disease at the last follow-up before death.<bold>Conclusions: </bold>Triple-negative breast cancer is associated with poor survival after recurrence. CNS recurrence is common, but death as a direct consequence of CNS progression in the setting of controlled systemic disease is uncommon. Thus, it does not appear that the high rate of CNS involvement is because of a sanctuary effect, but rather is due to the lack of effective therapies in general for this aggressive subtype of breast cancer. New treatment strategies are needed. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TRIPLE-negative breast cancer
*CENTRAL nervous system
*MEDICAL research
*DEATH
*DRUG therapy
*PROTEIN metabolism
*BREAST tumors
*CELL receptors
*COMPARATIVE studies
*RESEARCH methodology
*MEDICAL cooperation
*RESEARCH
*RESEARCH funding
*EVALUATION research
*DISEASE incidence
*RETROSPECTIVE studies
*KAPLAN-Meier estimator
CENTRAL nervous system tumors
Subjects
Details
- Language :
- English
- ISSN :
- 0008543X
- Volume :
- 113
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Cancer (0008543X)
- Publication Type :
- Academic Journal
- Accession number :
- 49125956
- Full Text :
- https://doi.org/10.1002/cncr.23930