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An Event-Related Potential Study of Response Inhibition in ADHD With and Without Prenatal Alcohol Exposure.
- Source :
-
Alcoholism: Clinical & Experimental Research . Apr2010, Vol. 34 Issue 4, p617-627. 11p. 2 Charts, 2 Graphs. - Publication Year :
- 2010
-
Abstract
- Background: The attention and cognitive problems seen in individuals with a history of prenatal alcohol exposure often resemble those associated with attention deficit hyperactivity disorder (ADHD), but few studies have directly assessed the unique influence of each on neurobehavioral outcomes. Methods: We recorded event-related potentials (ERPs) during a Go/No-go response inhibition task in young adults with prospectively obtained histories of prenatal alcohol exposure and childhood ADHD. Results: Regardless of prenatal alcohol exposure, participants with childhood ADHD were less accurate at inhibiting responses. However, only the ADHD group without prenatal alcohol exposure showed a markedly diminished P3 difference between No-go and Go, which may reflect a more effortful strategy related to inhibitory control at the neural processing level. Conclusion: This finding supports a growing body of evidence suggesting that the manifestation of idiopathic ADHD symptoms may stem from a neurophysiologic process that is different from the ADHD symptomatology associated with prenatal alcohol exposure. Individuals who have been prenatally exposed to alcohol and present with ADHD symptomatology may represent a unique endophenotype of the disorder, which may require different treatment approaches from those found to be effective with idiopathic ADHD. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- Volume :
- 34
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Alcoholism: Clinical & Experimental Research
- Publication Type :
- Academic Journal
- Accession number :
- 48744304
- Full Text :
- https://doi.org/10.1111/j.1530-0277.2009.01130.x