QUANTITATIVE SPECTROPHOTOMETRIC DETERMINATION OF ORNIDAZOLE TABLET FORMULATIONS USING IBUPROFEN SODIUM AS HYDROTROPIC SOLUBILIZING AGENT.

Various techniques are employed to enhance the aqueous solubility of poorly water-soluble drugs and hydrotropic solubilization is one of them. In the present investigation, hydrotropic solution of ibuprofen sodium (0.5M) was employed as solubilizing agent to solubilize the poorly water-soluble drug, ornidazole from fine power of its tablets for spectrophotometric determination. Ornidazole shows its maximum absorbance at 320 nm and Beer's law was obeyed in concentration range of 5-25 mcg/ml. Results of analysis were validated statistically and by recovery studies. The proposed method is new, simple, safe, environmentally friendly, accurate and cost-effective and can be successfully employed in routine to analyze ornidazole tablets. Hydrotropic agent and commonly used tablet additives did not interfere in the analysis. [ABSTRACT FROM AUTHOR]