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A transcriptional corepressor of Stat1 with an essential LXXLL signature motif.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America . 03/13/2001, Vol. 98 Issue 6, p3203. 5p. 12 Diagrams, 4 Graphs. - Publication Year :
- 2001
-
Abstract
- Reports that a member of the protein inhibitor of activated STAT family, PIASy, is a transcriptional corepressor of signal transducer and activator of transcription (Stat1). Presence of an LXXLL coregulator signature motif near the NH2 terminus of PIASy; Proposed mechanism of how PIAS proteins repress STAT-mediated gene activation.
- Subjects :
- *PROTEINS
*GENETIC transcription
*CHEMICAL inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 00278424
- Volume :
- 98
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 4857212
- Full Text :
- https://doi.org/10.1073/pnas.051489598