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Common variants near TERC are associated with mean telomere length.
- Source :
-
Nature Genetics . Mar2010, Vol. 42 Issue 3, p197-199. 3p. 1 Chart, 1 Graph. - Publication Year :
- 2010
-
Abstract
- We conducted genome-wide association analyses of mean leukocyte telomere length in 2,917 individuals, with follow-up replication in 9,492 individuals. We identified an association with telomere length on 3q26 (rs12696304, combined P = 3.72 × 10−14) at a locus that includes TERC, which encodes the telomerase RNA component. Each copy of the minor allele of rs12696304 was associated with an ∼75-base-pair reduction in mean telomere length, equivalent to ∼3.6 years of age-related telomere-length attrition. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TELOMERES
*CHROMOSOMES
*GENOMES
*LEUCOCYTES
*RNA
Subjects
Details
- Language :
- English
- ISSN :
- 10614036
- Volume :
- 42
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Nature Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 48279658
- Full Text :
- https://doi.org/10.1038/ng.532