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Transforming growth factor-beta: A target for cancer therapy.
- Source :
-
Journal of Immunotoxicology . Mar2010, Vol. 7 Issue 1, p15-26. 12p. 3 Diagrams, 1 Chart. - Publication Year :
- 2010
-
Abstract
- Transforming growth factor-beta (TGF-β) is a pleiotropic growth factor that regulates cell growth and differentiation, apoptosis, cell motility, extracellular matrix production, angiogenesis, and cellular immune responses. TGF-β demonstrates paradoxical action whereby it can function to suppress early tumorigenesis; however, it can also facilitate malignant transformation and stimulate tumor growth by manipulating a more hospitable environment for tumor invasion and the development of metastases. Given the integral role of TGF-β in transformation and cancer progression, various components of the TGF-β signaling pathway offer potentially attractive therapeutic targets for cancer treatment. This review focuses on the role of TGF-β in cancer and discusses both small and large molecule drugs currently in development that target TGF-β, its receptor and important down stream steps along its signaling pathway. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1547691X
- Volume :
- 7
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Immunotoxicology
- Publication Type :
- Academic Journal
- Accession number :
- 48219335
- Full Text :
- https://doi.org/10.3109/15476910903389920