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l-Serine synthesis in the central nervous system: A review on serine deficiency disorders
- Source :
-
Molecular Genetics & Metabolism . Mar2010, Vol. 99 Issue 3, p256-262. 7p. - Publication Year :
- 2010
-
Abstract
- Abstract: The de novo synthesis of the amino acid l-serine plays an essential role in the development and functioning of the central nervous system (CNS). l-Serine displays many metabolic functions during different developmental stages; among its functions providing precursors for amino acids, protein synthesis, nucleotide synthesis, neurotransmitter synthesis and l-serine derived lipids. Patients with congenital defects in the l-serine synthesizing enzymes present with severe neurological abnormalities and underscore the importance of this synthetic pathway. In this review, we will discuss the cellular functions of the l-serine pathway, structure and enzymatic properties of the enzymes involved and genetic defects associated with this pathway. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 10967192
- Volume :
- 99
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Molecular Genetics & Metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 48120301
- Full Text :
- https://doi.org/10.1016/j.ymgme.2009.10.012