LRRK2 and Parkin mutations in a family with parkinsonism—Lack of genotype–phenotype correlation

Abstract: Here we report the relationship between age at onset, clinical course and genotype in a family with combined LRRK2 G2019S and Parkin exon 2 deletions. In the combined mutation carriers the age at onset and clinical course was highly variable and not always younger than in the carriers of LRRK2 G2019S mutations alone. [Copyright &y& Elsevier]