Back to Search
Start Over
Ethanol co-administration moderates 3,4-methylenedioxymethamphetamine effects on human physiology.
- Source :
-
Journal of Psychopharmacology . Feb2010, Vol. 24 Issue 2, p165-174. 10p. - Publication Year :
- 2010
-
Abstract
- Alcohol is frequently used in combination with 3,4-methylenedioxymethamphetamine (MDMA). Both drugs affect cardiovascular function, hydration and temperature regulation, but may have partly opposing effects. The present study aims to assess the acute physiologic effects of (co-) administration of MDMA and ethanol over time. A fourway, double blind, randomized, crossover, placebo-controlled study in 16 healthy volunteers (9 male and 7 female) between the ages of 18 and 29. MDMA (100 mg) was given orally and blood ethanol concentration was maintained at pseudo-steady state levels of 0.6‰ by a three-hour 10% intravenous ethanol clamp. Cardiovascular function, temperature and hydration measures were recorded throughout the study days. Ethanol did not significantly affect physiologic function, with the exception of a short lasting increase in heart rate. MDMA potently increased heart rate and blood pressure and induced fluid retention as well as an increase in temperature. Co-administration of ethanol with MDMA did not affect cardiovascular function compared to the MDMA alone condition, but attenuated the effects of MDMA on fluid retention and showed a trend for attenuation of MDMA-induced temperature increase. In conclusion, coadministration of ethanol and MDMA did not exacerbate physiologic effects compared to all other drug conditions, and moderated some effects of MDMA alone. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02698811
- Volume :
- 24
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Psychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 48107824
- Full Text :
- https://doi.org/10.1177/0269881108100020