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Fibrillation and sharp-waves: Do we need them to diagnose ALS?
- Source :
-
Amyotrophic Lateral Sclerosis & Other Motor Neuron Disorders . Dec99, Vol. 1 Issue 1, p29-32. 4p. - Publication Year :
- 1999
-
Abstract
- BACKGROUND: Fibrillation/sharp-waves (fibs-sw) are considered an essential neurophysiological marker in Amyotrophic Lateral Sclerosis (ALS). We investigated how frequently an initial electrophysiological (EMG) evaluation, performed in ALS patients, revealed no fibs-sw. METHODS: The initial EMG studies from 68 ALS patients were analysed. The presence of fibs-sw in at least two muscles of each limb and two cranial-innervated muscles was assessed. RESULTS: We observed no fibs-sw in cranial-innervated muscles, and 7/15 bulbar-onset patients had no fibs-sw in limb muscles. Two of 28 upper-limb-onset patients, who had a short history before EMG, showed no fibs-sw. All lower-limb-onset patients had fibs-sw. Generally patients with no fibs-sw had diffuse abundant fasciculations. CONCLUSIONS: The absence of fibs-sw should not necessarily preclude the neurophysiological diagnosis of ALS in bulbar-onset patients. Early affected upper-limb-onset patients might show no fibs-sw, but profuse fasciculations associated with mild to moderate denervation–reinnervation in weak muscles are found. (Amyot Lat Scler 1999: 1:29–32). [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14660822
- Volume :
- 1
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Amyotrophic Lateral Sclerosis & Other Motor Neuron Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 4801977