Back to Search
Start Over
Restoration of reversed whole PTH/intact PTH ratio and reduction in parathyroid gland vascularity during cinacalcet therapy for severe hyperparathyroidism in a uraemic patient.
- Source :
-
Nephrology Dialysis Transplantation . Feb2010, Vol. 25 Issue 2, p638-641. 4p. 1 Graph. - Publication Year :
- 2010
-
Abstract
- Parathyroid hormone (PTH) levels measured with the intact PTH assays are generally higher than those measured with the whole PTH assay; however, rare exceptions to this rule have been reported in patients with severe hyperparathyroidism associated with N-PTH overproduction. We report a haemodialysis patient with severe secondary hyperparathyroidism, in whom abnormally higher whole PTH levels than intact PTH levels were normalized during cinacalcet therapy. Moreover, we observed a marked reduction in parathyroid gland vascularity during this treatment. Our findings suggested that increased sensitivity of the parathyroid calcium sensing receptor by calcimimetics may modulate the secretion or truncation of N-PTH or other PTH molecules that can be detected by the whole PTH assay but not by the intact PTH assays. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 09310509
- Volume :
- 25
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Nephrology Dialysis Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 47988303
- Full Text :
- https://doi.org/10.1093/ndt/gfp578