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The idiotype connection: linking infection and multiple sclerosis
- Source :
-
Trends in Immunology . Feb2010, Vol. 31 Issue 2, p56-62. 7p. - Publication Year :
- 2010
-
Abstract
- B cells present idiotopes (Id) from their B cell receptor to Id-specific CD4+ T cells. Chronic Id-driven T-B cell collaboration can cause autoimmune disease in mice. We propose that Id-driven T-B cell collaboration mediates the development of multiple sclerosis by perpetuating immune responses initiated against infectious agents. During germinal centre reactions, B cells express a multitude of mutated Ids. While most mutations lead to decreased affinity and deletion of the B cell, some B cells could be rescued by Id-specific T cells. Such Id-connected T-B cell pairs might initiate inflammatory foci in the central nervous system. This model may explain the intrathecal synthesis of low-avidity IgG against viruses, and the synthesis of oligoclonal IgG with unknown specificity in multiple sclerosis. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 14714906
- Volume :
- 31
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Trends in Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 47826317
- Full Text :
- https://doi.org/10.1016/j.it.2009.11.001