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Liver Transplantation in Japanese and Australian/New Zealand Children with Biliary Atresia: a 10-year Comparative Study.
- Source :
-
European Journal of Surgery . May99, Vol. 165 Issue 5, p454-459. 6p. - Publication Year :
- 1999
-
Abstract
- Objective: To compare Japanese with Australian/New Zealand (ANZ) children with biliary atresia who were treated by liver transplantation, and evaluate the indications for and timing of transplantation. Design: Retrospective study. Setting: Queensland Liver Transplant Service (QLTS), Australia. Subjects: 43 Japanese and 30 ANZ children with biliary atresia who required transplantation between 1985 and 1992. Interventions: The 43 Japanese children had 52 transplants, and the 30 ANZ children had 33. Main outcome measures: Morbidity, mortality, and long term survival. Results: The Japanese children had significantly lower serum albumin concentrations than the ANZ children preoperatively (mean (SD) 32 (7) g/L compared with 37 (5), p < 0.05). The actuarial survival at 7 years of the ANZ children was significantly higher than that of the Japanese children (79% compared with 49%, p < 0.05). There were 24 deaths (17 Japanese, 40%, and 7 ANZ, 23%); 2 of the ANZ and 7 of the Japanese children died more than a year after transplantation. All 26 children who were well-nourished at the time of transplantation defined as a Z-score (weight or height minus mean weight or height for age, sex, and race, divided by the SD) of -1 or more were alive at 1 month compared with 11 of the 47 poorly-nourished children (Z-score <-1). Survival among the Japanese declined after 1 year, and there was no association with Z-scores. Overall, Z-scores for weight improved significantly after transplantation, whereas those for height improved a little, but not significantly so. Japanese children were significantly shorter than ANZ children, and their Z-scores for height did not improve after transplantation. Conclusion: liver transplantation should be done as soon as possible for children with biliary atresia to maximise survival and growth. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 11024151
- Volume :
- 165
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- European Journal of Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 4779111
- Full Text :
- https://doi.org/10.1080/110241599750006695