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Functional evidence confirmed by histological localization: overlapping expression of erythropoietin and HIF-2α in interstitial fibroblasts of the renal cortex.
- Source :
-
Kidney International . Feb2010, Vol. 77 Issue 4, p269-271. 3p. 1 Diagram. - Publication Year :
- 2010
-
Abstract
- Erythropoietin (EPO) is the central hormone in the regulation of erythropoiesis. Synthesis of EPO and its constitutive release into the circulation are controlled by the transcriptional activity of the EPO gene. A key regulator of EPO is the dimeric hypoxia-inducible transcription factor (HIF), which has three isoforms. Paliege and co-workers provide convincing morphological evidence that it is the HIF-2 isoform that essentially triggers EPO in the kidney, which is the primary source of EPO in the body. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ERYTHROPOIETIN
*ERYTHROPOIESIS
*HYPOXEMIA
*TRANSCRIPTION factors
*KIDNEYS
Subjects
Details
- Language :
- English
- ISSN :
- 00852538
- Volume :
- 77
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Kidney International
- Publication Type :
- Academic Journal
- Accession number :
- 47770958
- Full Text :
- https://doi.org/10.1038/ki.2009.470