Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: A double-blind randomized placebo controlled trial.

The article presents a study that compares the effects of nitroglycerin on sublingual sidestream dark field and systemic hemodynamic guidelines in septic patients after a strict resuscitation protocol incorporated from a randomized placebo controlled trial. Patients were randomly assigned to receive nitroglycerin or placebo treatment after fulfillment of systemic hemodynamic end points. Results conclude that intravenous nitroglycerin does not promote sublingual microcirculatory blood flow.