The clinical patterns and molecular genetics of lissencephaly and subcortical band heterotopia.

The article presents information on the molecular genetics and clinical patterns of lissencephaly (LIS) and subcortical band heterotopia. It is stated that LIS and the related malformation subcortical band heterotopia are classic malformations associated with deficient neuronal migration and abnormal formation of cerebral convolutions or gyri. It mentions that first casual LIS gene was reported in 1993 and to date, there are six different genes including ARX, DCX, LISI.