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PET/CT in the evaluation of inflammatory bowel disease: studies in patients before and after treatment.
- Source :
-
Molecular Imaging & Biology . Feb2010, Vol. 12 Issue 1, p85-88. 4p. - Publication Year :
- 2010
-
Abstract
- <bold>Purpose: </bold>The purpose of this study was to evaluate the appropriate 2-deoxy-2-[(18)F]fluoro-D-glucose-positron emission tomography (FDG-PET) determination in patients with inflammatory bowel disease (IBD) before and after clinical improvement to see if this determination correlates with clinical activity.<bold>Procedures: </bold>We performed PET-computed tomography (PET/CT) on five patients before and after successful medical therapy in patients with moderately active IBD. Each patient had five bowel segments scored (0-3) for the appropriate FDG-PET determination.<bold>Results: </bold>There were five patients [Crohn's disease (CD) = 3, ulcerative colitis = 2] who were studied an average of 437 days (range, 77-807) after initial PET/CT scan. All patients showed significant improvement in physician global assessment scores (p = 0.004) and underwent repeat PET/CT. The total score of all segments was 32 pretreatment and 14 posttreatment (p < 0.01). Of 11 pretreatment active segments, nine (82%) segments either became inactive or displayed decreased activity, while two showed no change (p < 0.001).<bold>Conclusion: </bold>Appropriate FDG-PET determination decreases with successful treatment of inflammation in active IBD and correlates with symptom improvement. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15361632
- Volume :
- 12
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Molecular Imaging & Biology
- Publication Type :
- Academic Journal
- Accession number :
- 47528707
- Full Text :
- https://doi.org/10.1007/s11307-009-0232-1