Back to Search
Start Over
A Genome-Wide Association Study of Social and Non-Social Autistic-Like Traits in the General Population Using Pooled DNA, 500 K SNP Microarrays and Both Community and Diagnosed Autism Replication Samples.
- Source :
-
Behavior Genetics . Jan2010, Vol. 40 Issue 1, p31-45. 15p. 2 Charts, 4 Graphs. - Publication Year :
- 2010
-
Abstract
- Two separate genome-wide association studies were conducted to identify single nucleotide polymorphisms (SNPs) associated with social and nonsocial autistic-like traits. We predicted that we would find SNPs associated with social and non-social autistic-like traits and that different SNPs would be associated with social and nonsocial. In Stage 1, each study screened for allele frequency differences in ~430,000 autosomal SNPs using pooled DNA on microarrays in high-scoring versus low-scoring boys from a general population sample ( N = ~400/group). In Stage 2, 22 and 20 SNPs in the social and non-social studies, respectively, were tested for QTL association by individually genotyping an independent community sample of 1,400 boys. One SNP (rs11894053) was nominally associated ( P < .05, uncorrected for multiple testing) with social autistic-like traits. When the sample was increased by adding females, 2 additional SNPs were nominally significant ( P < .05). These 3 SNPs, however, showed no significant association in transmission disequilibrium analyses of diagnosed ASD families. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NUCLEOTIDES
*GENETIC polymorphisms
*AUTISM
*DNA microarrays
*GENE frequency
Subjects
Details
- Language :
- English
- ISSN :
- 00018244
- Volume :
- 40
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Behavior Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 47145531
- Full Text :
- https://doi.org/10.1007/s10519-009-9308-6