N-Acylhomoserine lactones involved in quorum sensing control the type VI secretion system, biofilm formation, protease production, and in vivo virulence in a clinical isolate of Aeromonas hydrophila.

The article presents a study that examines the role of N-acylhomoserine lactone(s) (AHLs) in the virulence of a human pathogen Aeromonas hydrophila. The study conducted complementation involving A. hydrophila, detection of lactone production, and measurement of protease and cytotoxic activity. The study concludes that AHL-mediated quorum sensing (QS) regulates the virulence of A. hydrophila through the type VI secretion system (T6SS), biofilm formation and metalloprotease production.