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Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1.
- Source :
-
Nature Neuroscience . Jan2010, Vol. 13 Issue 1, p22-24. 3p. 3 Diagrams. - Publication Year :
- 2010
-
Abstract
- In cultured rat hippocampal neurons, we found that thrombospondin 1 (TSP1) increased the speed of synapse formation in young neurons, but not the final density of synapses in mature neurons. TSP1 interacted with neuroligin 1 (NL1) and application of the NL1 extracellular domain blocked TSP1-induced synaptogenesis. Furthermore, knocking down endogenous NL1 inhibited TSP1's effect. Our results indicate that TSP1 accelerates the speed of synaptogenesis through NL1 in hippocampal neurons. [ABSTRACT FROM AUTHOR]
- Subjects :
- *THROMBOSPONDINS
*SYNAPSES
*NEURONS
*NEURAL transmission
*NEURAL circuitry
Subjects
Details
- Language :
- English
- ISSN :
- 10976256
- Volume :
- 13
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Nature Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 47126918
- Full Text :
- https://doi.org/10.1038/nn.2459