Antibacterial clerodane diterpenes from Goldenrod (Solidago virgaurea)

Authors :: Starks, Courtney M.
Williams, Russell B.
Goering, Matt G.
O’Neil-Johnson, Mark
Norman, Vanessa L.
Hu, Jin-Feng
Garo, Eliane
Hough, Grayson W.
Rice, Stephanie M.
Eldridge, Gary R.
Source :: Phytochemistry. Jan2010, Vol. 71 Issue 1, p104-109. 6p.
Publication Year :: 2010
Abstract: Abstract: Nine clerodane diterpenes, solidagoic acids C-I (1–7), cleroda-3,13(14)-dien-16,15:18,19-diolide (8) and cleroda-3,13(14)-dien-15,16:18,19-diolide (9) were isolated and characterised from the ethanol–ethyl acetate (1:1) extract of Solidago virgaurea. The structures were determined by NMR spectroscopic analysis. Several displayed moderate antibacterial activity against Staphylococcus aureus. [Copyright &y& Elsevier]