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Abuse liability of the anesthetic propofol: self-administration of propofol in rats under fixed-ratio schedules of drug delivery.
- Source :
-
Psychopharmacology . 2000, Vol. 153 Issue 1, p148. 7p. - Publication Year :
- 2000
-
Abstract
- Abstract Rationale: Previous reports suggest that propofol (PPF) may have abuse potential in humans. Hence, we hypothesized that PPF could reinforce sell-administration behavior in other species. Positive reinforcing effects of PPF could be interpreted as an index of abuse liability. Objective: Acquisition and maintenance of i.v. PPF self-administration were examined in 12 rats. Methods: Six rats were initially given access to methohexital (MHX, 2.0 mg/kg per infusion) under a fixed ratio (FR) 1 schedule, while the other six were initially given access to PPF (1.7 mg/kg per infusion). Once stable responding was established, various doses of PPF (0.56, 1.0, and 1.7 mg/kg per infusion) and vehicle (Intralipid 20%) were made available. Results: The number of PPF infusions per session was an inverse function of dose, with 0.56 mg/kg and 1.0 mg/kg per infusion maintaining significantly more infusions per session than vehicle in most rats under the FR 1 schedule. For some rats, the number of vehicle infusions per session was equal to or greater than the number of PPF infusions. Increasing the response requirement to FR 5 decreased the number of vehicle infusions per session in these rats, while PPF maintained a higher number of infusions than vehicle under this FR value in six of seven rats. Conclusion: PPF served as a reinforcer in rats under FR schedules of i.v. drug delivery, adding to the extant evidence that it has abuse potential. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANESTHETICS
*RATS
Subjects
Details
- Language :
- English
- ISSN :
- 00333158
- Volume :
- 153
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Psychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 4693673
- Full Text :
- https://doi.org/10.1007/s002130000430