Association between TaqI A dopamine D[sub 2] receptor polymorphism and therapeutic response to bromperidol: a preliminary report.

Abstract The relationship between TaqI A dopamine D[sub 2] receptor (DRD[sub 2]) polymorphism and therapeutic response to bromperidol, a selective dopamine antagonist, was investigated in 30 acutely exacerbated schizophrenic inpatients. Patients were treated with bromperidol 6-18 mg/day for 3 weeks. Clinical symptoms were evaluated by the Brief Psychiatric Rating Scale (BPRS) before and 3 weeks after the treatment. The TaqI A genotypes were determined with the PCR method. There was no significant difference in the percentage improvement of total BPRS or 5-subgrouped symptoms (positive, negative, anxiety-depression, excitement and cognitive symptoms) after the 3-week treatment between the patients with A1 alleles (n=18) and those with no A1 allele (n=12). Although the present study is preliminary, it is suggested that the TaqI A DRD[sub 2] polymorphism is not associated with therapeutic response to bromperidol in schizophrenic patients. [ABSTRACT FROM AUTHOR]