Palladium-catalyzed cyclization of 1,6-enyne with 2-bromoarylaldehyde: domino sequence to [5-7-6] tricyclic ring systems

Authors :: Fang, Xianjie
Tong, Xiaofeng
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Jan2010, Vol. 51 Issue 2, p317-320. 4p.
Publication Year :: 2010
Abstract: Abstract: A domino sequence of cyclization of 1,6-enyne with 2-bromoarylaldehyde followed by the intramolecular Aldol-condensation has been realized in the presence of 5mol% of palladium catalyst. This sequence provides a convenient protocol to access polycyclic ring systems with readily available starting materials under simple Pd(0)-catalyzed conditions. The intramolecular Aldol-condensation has been proposed as the key step for the catalytic cycle. [Copyright &y& Elsevier]

Subjects :: *PALLADIUM catalysts
*RING formation (Chemistry)
*ALDEHYDES
*ALDOL condensation
*POLYCYCLIC compounds
*FUNCTIONAL groups

Language :: English
ISSN :: 00404039
Volume :: 51
Issue :: 2
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 46748598
Full Text :: https://doi.org/10.1016/j.tetlet.2009.11.006

Full Text Access

Tools