Fast production of highly concentrated reactive [18F] fluoride for aliphatic and aromatic nucleophilic radiolabelling

Authors :: Aerts, Joël
Voccia, Samuel
Lemaire, Christian
Giacomelli, Fabrice
Goblet, David
Thonon, David
Plenevaux, Alain
Warnock, Geoffrey
Luxen, André
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Jan2010, Vol. 51 Issue 1, p64-66. 3p.
Publication Year :: 2010
Abstract: Abstract: The use of a polymeric solid support loaded with a long alkyl chain quaternary ammonium allows the rapid and efficient recovery of cyclotron produced [18F]F− from [18O]water to a low water content organic solution compatible with fast nucleophilic labelling of most precursors for PET radiopharmaceuticals in high yield. [Copyright &y& Elsevier]

Subjects :: *REACTIVITY (Chemistry)
*FLUORIDES
*ALIPHATIC compounds
*AROMATIC compounds
*NUCLEOPHILIC reactions
*AMMONIUM compounds
*RADIOPHARMACEUTICALS
*POSITRON emission tomography

Language :: English
ISSN :: 00404039
Volume :: 51
Issue :: 1
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 45639008
Full Text :: https://doi.org/10.1016/j.tetlet.2009.10.085

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