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Heart failure and endothelin receptor antagonists.

Authors :
Miyauchi, Takashi
Goto, Katsutoshi
Source :
Trends in Pharmacological Sciences. May99, Vol. 20 Issue 5, p210. 8p.
Publication Year :
1999

Abstract

Presents evidence that an endothelin receptor antagonist is a useful drug for the treatment of heart failure. How endothelin-1 exerts long-term effects, such as myocardial hypertrophy, and causes cellular injury in cardiac myocytes; Thought that myocardial endothelin system appears to be an important target for therapeutic intervention in heart failure.

Subjects

Subjects :
*ENDOTHELINS
*HEART failure treatment
*MUSCLE cells
*CARDIAC hypertrophy

Details

Language :
English
ISSN :
01656147
Volume :
20
Issue :
5
Database :
Academic Search Index
Journal :
Trends in Pharmacological Sciences
Publication Type :
Academic Journal
Accession number :
4556749
Full Text :
https://doi.org/10.1016/S0165-6147(99)01297-3
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