Back to Search
Start Over
Comparison of the Effects of Low Intra-Abdominal Pressure and Pentoxifylline on Oxidative Stress during CO2 Pneumoperitoneum in Rabbits.
- Source :
-
European Surgical Research . 2009, Vol. 43 Issue 4, p330-337. 8p. 4 Charts. - Publication Year :
- 2009
-
Abstract
- Background: The aim of this study was to investigate the effect of low-pressure pneumoperitoneum and pentoxifylline, a methylxanthine derivative, in the prevention of injury caused by free oxygen radicals generated during CO2 pneumoperitoneum. Methods: Twenty-eight rabbits were allocated randomly to 4 groups. Control group rabbits (group 1) were subjected to anesthesia for 60 min; group 2 and 3 animals were subjected to a CO2 pneumoperitoneum (15 or 7 mm Hg); and group 4 rabbits received 50 mg/kg pentoxifylline, followed by a 15-mm-Hg pneumoperitoneum. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), lipid hydroperoxide, glutathione reductase and total antioxidant status were measured. Results: Compared with group 1, a significant increase in lipid hydroperoxide levels at the end of the pneumoperitoneum and 30 min after deflation and a significant decrease in total antioxidant status 24 h after deflation were recorded in group 2. In addition, a significant increase was observed in ALT, AST and LDH levels. These changes were attenuated by low-pressure pneumoperitoneum, whereas pentoxifylline pretreatment appeared to attenuate only transaminase levels. Conclusion: Low-pressure pneumoperitoneum could attenuate ischemia/reperfusion injury induced by CO2 pneumoperitoneum in a rabbit model whereas pentoxifylline pretreatment appeared to attenuate only transaminase levels. Pentoxifylline did not prevent the development of oxidative stress. Copyright © 2009 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0014312X
- Volume :
- 43
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- European Surgical Research
- Publication Type :
- Academic Journal
- Accession number :
- 45273568
- Full Text :
- https://doi.org/10.1159/000237747